NMN

The Answer NMN (500mg) - Nicotinamide Mononucleotide

 

Slow the effects of ageing!

• Boost energy and metabolism!
• Reduce joint pain!
• Brain and heart health!
• Live a healthier longer life!

 

What is NMN and what does it do?

Put simply, NMN is an amazing ingredient that research has shown can help slow many of the effects of ageing!

This amazing ingredient is a natural enzyme found in all living cells and has a very important role in a number of biological processes in your body.

NMN also has excellent bioavailability, which means it can be absorbed easier, so your body can use it better!

Each tablet contains 500mg of NMN in an easy to swallow capsule.

 

Research shows the benefits of taking NMN!

There is a lot of important research on NMN that has supported the amazing benefits reported by people around the world. Below is a list of just some of the potential benefits of taking NMN.

 

Boosts Energy and Metabolism

• NMN consumption leads to higher ATP levels, indicating an increase in mitochondria activity (Ref 21). Adenosine Triphosphate (ATP) stores and provides energy for all cells in our bodies. Mitochondria are the energy centres (little power stations) in energy cell in our bodies.

So what does this mean?

When you eat/rest your body stores energy to use later (the excess energy that can’t be stored becomes fat). So higher ATP means a bigger battery in your cells therefore you can store more energy (so your body has more energy to use!)

Increased mitochondria activity means those batteries are working at a higher voltage, so your body’s natural processes are working more effectively

 

Reduces Inflammation

• NMN has been shown to reduce inflammatory responses, which suggests NMN supplementation can play an important role in the treatment of chronic or acute inflammation (Ref 22).

 

Reduces Joint Pain and Arthritic pain

• NMN reduces inflammation and swelling (Ref 22), which are both key factors in alleviating joint pain and arthritic pain
• A clinical study shows that post-menopausal women supplementing with NMN (over 8 weeks) reported improvements in allergies, joint pain, and overall wellbeing (Ref 23).

 

DNA Repair & Longevity

• NMN, by replenishing NAD+ in the body, reduces the side effects of chemotherapy, protecting against radiation exposure, and repairs DNA damage from stress and old age the slowing of age-related decline in DNA repair (Ref 14).
• NMN increases Telomere length in middle-aged adults. As we get older, Telomeres shorten, leading to age-related disorders (metabolic and heart diseases etc.). Restoring Telomere length can prevent use age-related disorders and increase lifespan (Ref 15).
• A study developed an “ageing clock” to demonstrate that NMN has a rejuvenation effect, so effectively reducing biological age (Ref 16).

 

Brain Function/stroke onset

• Studies have shown that NMN reduces neurodegeneration, even with Alzheimer’s (Ref 1).
• Blood vessel health deteriorates as we age, impacting blood flow to our brains, which can cause cognitive impairments. NMN has been shown to increase flow to the brain, improving cognitive function (Ref 2).
• Impaired blood vessels in the brain can lead to a stroke due to damage to brain tissue. NMN has been shown to delay stroke onset (Ref 3) and stroke damage (Ref 4).

 

Healthy Heart

• NMN has been shown to protect against heart failure by normalising mitochondrial balance (mitochondria are the energy centres / power stations in all human cells) and maintaining heart function (Ref 8).
• Heart tissue doesn’t regenerate. Instead, damaged heart tissue shows scarring which leads to dysfunction. NMN recovers heart function by reducing this scarring. It restores the heart’s size and thickness (Ref 9)

 

Improves Muscle Function

• With age, muscles lose their ability to regenerate and grow. Studies suggest NMN reverses these issues, increasing strength and physical endurance (Ref 5).
• A study has shown NMN at 250mg per day for 12 weeks improves muscle strength and performance in older men (Ref 6)

 

Helps with type 2 diabetes

• NMN improves glucose uptake in various tissues, including adipose tissue, muscle, and the brain (Ref 25). Glucose uptake and utilisation is key to the prevention to type 2 diabetes, and in supporting individuals that have type 2 diabetes.

 

Skin and Skin Aging        

• Supplementing with NMN reduces the formation of wrinkles (Ref 18).
• Eczema, also known as Atopic dermatitis, is a chronic inflammatory skin disease. A study showed that NMN reduced potent anti-inflammatory properties, demonstrating a positive effect in relieving the symptoms of atopic dermatitis (Ref 20).

 

Research and study references:

 

Ref 1: Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death
Xiaonan Wang et al
https://pubmed.ncbi.nlm.nih.gov/27130898/

Ref 2: Nicotinamide mononucleotide (NMN) supplementation rescues Cerebro microvascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
Tarantini et al
https://pubmed.ncbi.nlm.nih.gov/31015147/

Ref 3: Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence
Forte et al
https://pmc.ncbi.nlm.nih.gov/articles/PMC7469607/

Ref 4: Mechanisms of transformation of nicotinamide mononucleotides to cerebral infarction haemorrhage based on MCAO model
Shu et al
https://pmc.ncbi.nlm.nih.gov/articles/PMC7042676/

Ref 5: Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
Ito et al
https://pubmed.ncbi.nlm.nih.gov/35905718/

Ref 6: Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men
Igarashi et al
https://pmc.ncbi.nlm.nih.gov/articles/PMC9158788/#:~:text=These%20findings%20indicate%20that%20the,affect%20the%20skeletal%20muscle%20mass.

Ref 7: Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study
Liao et al
https://pubmed.ncbi.nlm.nih.gov/34238308/

Ref 8: Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure
Zhang et al
https://pubmed.ncbi.nlm.nih.gov/28882480/

Ref 9: Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation
Wu et al
https://pubmed.ncbi.nlm.nih.gov/33675899/

Ref 10: Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD⁺ redox
Yang et al
https://pubmed.ncbi.nlm.nih.gov/32744417/

Ref 11: Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes
Miao et al
https://pubmed.ncbi.nlm.nih.gov/32755581/

Ref 12: Nicotinamide Mononucleotide Restores the Meiotic Competency of Porcine Oocytes Exposed to Ethylene Glycol Butyl Ether
Miao et al
https://pubmed.ncbi.nlm.nih.gov/33604339/

Ref: 13: Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway
Ma et al
https://pmc.ncbi.nlm.nih.gov/articles/PMC9828322/

Ref 14: Li J, Bonkowski MS, Moniot S, et al. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging
Li et al
https://pubmed.ncbi.nlm.nih.gov/28336669/

Ref 15: The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase.
Niu et al
https://pubmed.ncbi.nlm.nih.gov/34912838/

Ref 16: Scale bar of aging trajectories for screening personal rejuvenation treatments
Shen et al
https://pmc.ncbi.nlm.nih.gov/articles/PMC9619353/

Ref 17: Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling
Brito et al
https://pubmed.ncbi.nlm.nih.gov/35610161/

Ref 18: The versatile multi-functional substance NMN: its unique characteristics, metabolic properties, pharmacodynamic effects, clinical trials, and diverse applications
Yu et al
https://pmc.ncbi.nlm.nih.gov/articles/PMC11473484/

Ref 19: β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice
Zhou et al
https://pubmed.ncbi.nlm.nih.gov/34675595/

Ref 20: Nicotinamide mononucleotide ameliorates DNFB-induced atopic dermatitis-like symptoms in mice by blocking activation of ROS-mediated JAK2/STAT5 signaling pathway
Gao et al
https://pubmed.ncbi.nlm.nih.gov/35533554/

Ref 21: Declining NAD⁺ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
Gomes et al
https://pmc.ncbi.nlm.nih.gov/articles/PMC4076149/

Ref 22: Nicotinamide mononucleotide (NMN) alleviates the poly(I:C)-induced inflammatory response in human primary cell cultures
Sano et al
https://pmc.ncbi.nlm.nih.gov/articles/PMC10359400/

Ref 23: Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications Benjamin et al

https://pmc.ncbi.nlm.nih.gov/articles/PMC11205942/

Ref 24: Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Yoshino et al
https://pubmed.ncbi.nlm.nih.gov/33888596/

Ref 25: Nicotinamide Mononucleotide (NMN) Works in Type 2 Diabetes through Unexpected Effects in Adipose Tissue, Not by Mitochondrial Biogenesis
Popescu et al
https://pmc.ncbi.nlm.nih.gov/articles/PMC10932336